The Estadio Brigadier General Estanislao López in Santa Fe is more commonly referred to as El Cementerio de Los Elefantes (The Elephant’s cemetery) due to the number of big clubs who come undone at the ground. The name dates back to a victory over Brazilian giants Santos in 1964 but on Thursday evening, Colón took a fresh victim in the form of three-time Copa Libertadores champions São Paulo.

Matías Fritzler’s goal in Morumbi two weeks ago gave Colón a famous win but the second leg was always going to be difficult.

And so it proved. Nene had struck the crossbar with a first half free kick and Erik Godoy had raced back to clear off the Colón line to preserve the lead but with 20 minutes remaining a venomous Liziero strike from long range brought the Brazilians level.

The result took the tie to penalties and from Alan Ruíz tucking away the first, Colón were perfect from the spot. Leandro Burián saved from Bruno Alves and it left captain Guillermo Ortiz to blast in the fifth and final kick to seal victory.

With the last 16 bracket now complete, Colón face Colombian side Junior for a place in the quarter finals.